I remember back in 2000, when Penton moved us into a new building and cubicle hell, I developed symptoms of carpal tunnel syndrome. The new desks and what not did not agree with me at all.
That was about the time that I started using natural keyboards, and I've had one at every job, as well as at home. I'm most comfortable when I can be in a corner of some kind, able to get my arms up on the desk. This goes against the conventional wisdom about having it lower and all, but it's something that has worked for me for years.
But lately I've been spending more time on my laptop than anything else, and it's clear that my body is not pleased with this arrangement. I prefer using the laptop because the screen is higher resolution and much brighter and contrasty. I need to suck it up and use the desktop more.